Product Name :
β-synuclein, Human
Product Type :
Protein
Lot No :
QMY03
Reactivity :
Human
Storage :
Shipped at 4°C. Store at -20°C. After reconstitution, store at -80°C and avoid frequent freeze and thaw.
Composition :
Lyophilized from PBS pH7.4
Source :
Purified from E.coli expressing the human beta-synuclein gene (1-134aa, with N-His tag)
Molecular Weight :
16.6 kDa
Endotoxin activity :
Not tested
Usage :
200ul of distilled water will yield a concentration of 1mg/ml.
Form :
Lyophilized
Purity :
> 95% by SDS-PAGE
Expression system :
E.coli
Tag :
His tag
Origin :
Human
Background :
Synuclein is a small, soluble protein primarily expressed in neural tissue. The synuclein family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. alpha-Synuclein is a very conserved, small acidic protein (140 residues) with a molecular weight of approximately 19 kDa that accounts for about 1% of total protein in neurons. It is concentrated primarily in presynaptic axon terminals and plays a central role in initiating Parkinson's disease. It is the principal constituent of Lewy bodies which are formed by protein aggregation and inclusion body formation. alpha-Synuclein lacks secondary or tertiary structure, so it belongs to the family of natively unfolded proteins, many of which act as chaperones. Much of this alpha-synuclein has been post-translationally modified to increase the rate of oligomerization. Mutant forms of alpha-Synuclein are associated with autosomal dominant Parkinson's disease. The mutations increase the aggregation rate of the resultant alpha-synuclein beta-Synuclein is found primarily in brain tissue and is seen mainly in presynaptic terminals. It is predominantly expressed in the neocortex, hippocampus, striatum, thalamus, and cerebellum. beta-Synuclein may protect the central nervous system from the neurotoxic effects of alpha-synuclein by inhibiting aggregation of alpha-synuclein which occurs in neurodegenerative diseases such as Parkinson's disease. gamma-Synuclein is a synuclein protein found primarily in the peripheral nervous system (in primary sensory neurons, sympathetic neurons, and motor neurons) and retina. gamma-Synuclein expression in breast tumors is a marker for tumor progression.
Background reference :
1) Irvine GB et al. 2008, Mol Med. In press
2) Wakabayashi K et al. 2007, Neuropathology. 27(5):494-506.
3) Beyer K. Acta Neuropathol. 112(3):237-251.
4) Bruening W et al. 2000, Cancer. 88(9):2154-2163
Research area :
Neuroscience 
Database link - SwissProt no.
Q16143

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